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CerCell - Configurable batch Single-Use-Bioreactor

Customized Bioreactor. Let's design your preferred Single-Use-Bioreactor (SUB). No standard SUB will satisfy your needs anyway! Out of 5.000 different parts it should be possible to assemble a CerCell design specifically for you.

(PDF) Bioreactor Design - ResearchGate

6.2 BIOREACTORS BACKGROUND. The main objective of a properly designed bioreactor is to pr ovide a controlled environment to. . Small openings must be made lea k-proof with an O-ring, .

Laboratory Bioreactors / Fermentors| Reactors

Volume range: 0.2/1.0 liters Sterilization: Autoclavable Vessel: Borosilicate glass single wall vessel Parallel control: Yes (up to 24 units) Use: Bacterial/Cell Culture The Solaris IO Series is a mini fermentor/bioreactor suitable for small scale laboratory applications. It is available in two different H/D ratios and the ideal device for innovative parallel process development (up to 24 .

Development of a Scale-Down Model for rAAV Viral Vector .

same amount of bioreactors in one week whereas it takes two weeks in 2 L glass bioreactors." Using the DASbox system also helped reduce costs, by facilitating the performance of studies in small-scale bioreactors. A 1x105 1x106 02 448 72 V i a b l e a c e l l s e / m L Time (h) 300 rpm 400 rpm 375 rpm 2 L bioreactor, 180 rpm (n=6) B 2 14 16 .

Bioreactor Design and Operation - PDF Free Download

TABLE 18.5 Scale-Up Comparison from 75 to 10,000 L Bioreactor with Impeller Size to Fermentor Di/DR and Fermentor Shape Factor H/DR Remaining Constant Small fermentor, 75 L Production fermentor, 10,000 L Constant P0/V Constant u Constant uDi Constant Re 1 133.3333 3479.8823 26.0991 0.1957 P0 =Vfu3 D2i 1 1 26.0991 0.1957 0.0015 Impeller rotation .

Fermentation & Bioreactors | Sartorius

Discover the broadest selection of bioreactors & fermenters in the industry. Scalable from 8 mL up to 2,000 L, single-use or made from stainless steel!

Bioreactor

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Cell Culture Scale-Up in Stirred-Tank Single-Use Bioreactors

L a) describes the efficiency with which oxygen can be delivered to a bioreactor culture for a given set of parameter conditions. For proper cell culture scale-up, it is important to select equipment of different sizes with similar k L a capabilities so that small-scale success can be .

Minifors 2 - The complete entry-level bioreactor package .

Award-winning design for practical applications. The Minifors 2 has a compact, user-friendly design. With its small footprint and few external connections, the bench-top bioreactor takes up little space in the lab.

PubMed - National Center for Biotechnology Information

We evaluated the sparger kLa and kLaCO2 (CO 2 volumetric mass transfer coefficient) from a range of bioreactor scales (3-2,000 L) with different spargers. Results demonstrated that kLa for oxygen is not an issue when scaling from small-scale to large-scale bioreactors at the same gas .

Airlift Bioreactors - an overview | ScienceDirect Topics

Hesham A. El-Enshasy, in Bioprocessing for Value-Added Products from Renewable Resources, 2007. 5.1.7 Bioreactor type. Yin et al. [151] studied the cultivation of R. oryzae in a shake flask and in an air-lift bioreactor. When the inoculated spore concentrations were between 2×105 and 2×106 spores mL-1, cell morphology appeared as reduced fluffy and pellet mycelia, respectively.

Cell Culture Scale-Up in Stirred-Tank Single-Use Bioreactors

L a) describes the efficiency with which oxygen can be delivered to a bioreactor culture for a given set of parameter conditions. For proper cell culture scale-up, it is important to select equipment of different sizes with similar k L a capabilities so that small-scale success can be .

Simplify Upstream Process Development and Scale-Up: Single .

For example, cells first are grown in a 2-L shake flask or glass bioreactor, then in a 10-L glass bioreactor. When conditions have been optimized at small scale, a process then moves to a 50-L bioreactor before further scaling up to 250-L and 1,000-L bioreactors, with additional optimization as .

HyPerforma Single-Use Mixers | Thermo Fisher Scientific - US

The Thermo Scientific HyPerforma Single-Use Mixer (S.U.M.) has been designed using a proven engineered mixer platform design and offers a more ergonomic and efficient user experience for upstream and downstream mixing applications.The complete line of HyPerforma S.U.M.s includes 50, 100, 200, 500, 1,000 and 2,000 L .

Fermenters and Bioreactors | New and Used Lab Fermenters .

Industrial-scale fermenters, or bioreactors, are used for propagation of organisms for protein synthesis, or production of chemicals or drugs from chemical precursors. The scale, adaptability, and suitability are important considerations, as well as the requirements involved in breakdown and maintenance.

Development of a Scale-Down Model for rAAV Viral Vector .

same amount of bioreactors in one week whereas it takes two weeks in 2 L glass bioreactors." Using the DASbox system also helped reduce costs, by facilitating the performance of studies in small-scale bioreactors. A 1x105 1x106 02 448 72 V i a b l e a c e l l s e / m L Time (h) 300 rpm 400 rpm 375 rpm 2 L bioreactor, 180 rpm (n=6) B 2 14 16 .

Bioprocess - Eppendorf US

Bioreactors Working Volume Range Please select filter Small (250 mL – 2 L) Benchtop (1 – 20 L) Pilot/Production (20 – 1200 L) Number of parallel units Please select filter Single unit Up to 8 Up to 16

BioBLU ® c Single-Use Vessels - Eppendorf International

BioBLU ® 0.3c Single-Use Vessel, cell culture, open pipe, 1 pitched-blade impeller, no pH, sterile, 4 pieces Catalog No. 1386100000

Bioreactor

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Stainless Steel Bioreactors & Fermenters | Sartorius

The Sartorius portfolio of stainless steel fermenters and bioreactors includes standard products from 5 L to 200 L and customized engineering solutions up to 2,000 L. Our long-standing process knowledge combined with the unrivaled quality of our fermenter .

True to Scale: Benchtop Bioreactors

These include the SmartRocker rocker-type bioreactors up to 50 L, glass vessels ranging from 1 L to 15 L, and a single-use 3-L bioreactor. Single-use sizes of 1 L and 15 L are expected in early 2018.

Allegro™ XRS 25 Bioreactor System | Pall Shop

Under similar agitation conditions, the Allegro XRS 25 bioreactor system mixes almost 3 times faster than conventional rockers (Table 1), and demonstrates much higher mass transfer properties as measured by k L a values (Table 2).

Bioreactors (Stirred-tank) / Fermentors | Biocompare.com

Bioreactor types range from small, 1-L benchtop units to 10,000-L systems for large-scale industrial applications, and can be batch type or continuous flow, in which materials flow constantly through the unit. Tight control over parameters such as temperature, moisture, pH, oxygen, and stirring rate will produce the most satisfactory results .

Fermenter - Bioreactor | LAMBDA

MINIFOR laboratory fermentor and bioreactor. The LAMBDA MINIFOR bench-top autoclavable laboratory fermenter and bioreactor was developed as a result of the need to construct a small laboratory fermentor for working volume ranges from 35 ml to over 6 liters.. Based on long personal practical experience in fermentation and cell culture, a high quality fermentor-bioreactor which is .

Fermenters and Bioreactors | New and Used Lab Fermenters .

Industrial-scale fermenters, or bioreactors, are used for propagation of organisms for protein synthesis, or production of chemicals or drugs from chemical precursors. The scale, adaptability, and suitability are important considerations, as well as the requirements involved in breakdown and maintenance.

4 Process Involved in Scale up Criteria | Microbial .

Oxygen is only sparingly solube in cell culture medium (0.2 m mole O 2 I-1). Oxygen demand of a culture (10 6 cells per ml) ranges between 0.053 m mole O 2 l-1 h-1 and 0.59 m mole O 2 I-1 h-1 depending on the type of cell. Scale up of mammalian cell cultures are, therefore, bound by .

Single-use Stirred Tank Bioreactors

Improved handling - Reduced operator intervention and processing time. Excellent mixing performance - Shorter mixing times < 30 seconds and great power input for high kLa and CO 2 stripping . Optimized cleanroom footprint - Even the 2000 L bioreactor fits under 3 meters

Chapter 10: Sterilization and Bioreactor Operation

A 10,000 liter (of liquid) bioreactor contains 5 g /L of growing cells q O 2 = 20 mmole O 2 /(g cells˜hr) D T = 2 m, D i = 1 m, (6-blade turbine agitator) x 3 blades For 1 liquid volume per minute aeration rate (air), can the OTR = OUR for N = 100 rpm? C L = 1 mg O 2 /L

Jupiter Autoclave 2 to 10L Bioreactors - Fermenters .

Jupiter Multi: a single unit is composed by a Master Control Station that includes a controller and 27" touchscreen monitor, capable of running one to twenty four bioreactors They are equipped with electric thermostating or hot water recirculation loop, for bacteria or cell cultures, different automation and process control grades, wide .

Bioreactors - an overview | ScienceDirect Topics

L.E. Erickson, in Encyclopedia of Microbiology (Third Edition), 2009. Bioreactors are vessels or tanks in which whole cells or cell-free enzymes transform raw materials into biochemical products and/or less undesirable by-products. The microbial cell itself is a miniature bioreactor; other examples include shake flasks, Petri dishes, and industrial fermentors.