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CN1681508A - Novel inhibitors of kinases - Google Patents

The new kinase inhibitors. FIELD. (VEGFR-2FGFR-1) .

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AN EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS

Jul 31, 2013 · Catalytic amounts of 4-(dimethylamino)pyridine (0.26 g, 2 mmol) and alcohol 10D (10.4 g, 53 mmol) were then added into the mixture, followed by 100 mL of tetrahydrofuran to wash remaining reagents down. After stirring for 18 hours at 0 °C, cooling was removed, and the reaction mixture concentrated on rotovap (30 °C, 26 mm Hg) to yield 73 g of .

CN1826313A - Large-scale synthesis of selective androgen .

(ARTA) .

GLUTAMATE AGGRECANASE INHIBITORS - Patent application

Patent application title: GLUTAMATE AGGRECANASE INHIBITORS Inventors: David Brian How Joshua James Sabatini Phaik-Eng Sum Jason Shaoyun Xiang Tarek Suhayl Mansour Jerauld Stanley Skotnicki Steve Yik-Kai Tam Eric Feyfant Agents: WYETH;PATENT LAW GROUP Assignees: Wyeth Origin: MADISON, NJ US IPC8 Class: AA61K314965FI USPC Class: 51425506 Patent application number: .

The Hive - Discussing the chemistry of mind-altering compounds

RotoVap GAA from > 75% acetic acid solutions Ammonia Smell correlates to NH3 quality? . THF - OTC - 5L / 10L / 25 L / 50L DIY Catalytic Hydrogenation Apparatus w/ shaker hellman P-benzo is now watched in OZ? . Purification of Tetrahydrofuran TiO2 + UV for oxidation ? alpha-ethylstyrene synthesis (organometalic chem.) jm1309 4-ad to test

CN1681508A - Novel inhibitors of kinases - Google Patents

The new kinase inhibitors. FIELD. (VEGFR-2FGFR-1) .

Glutamate aggrecanase inhibitors - Wyeth

Jun 30, 2009 · What is claimed is: 1. A compound of the formula (I): or a pharmaceutically acceptable salt thereof, wherein W is —C(O); R 1 is biphenyl optionally substituted with one or more of R 5 or R 6, and when R 1 is substituted with more than one of R 5 or R 6, the substituents can be identical or different; R 2 is hydrogen; R 3 is —CO 2 H, —CONHOH, —CONHR 7, or —COOR 7; R 4 is —CONR 9 R .

CN1665817A - Process for preparing certain pyrrolotriazine .

The present invention relates to a general formula (1) certain pyrrolotriazine compounds and salts of pharmaceutically acceptable. Compounds of formula (1) can inhibit the growth factor receptors such as VEGFR-2 and FGFR-1 tyrosine kinase activity, and therefore they can be used as anticancer agents. Formula (1) compounds can also be used to treat other signal transduction by growth factor .

Boiling Point - Science topic

May 17, 2020 · Review and cite BOILING POINT protocol, troubleshooting and other methodology information | Contact experts in BOILING POINT to get answers

US Patent Application for Process For Preparing Dipeptidyl .

A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate .

patents.justia.com

RELATED APPLICATION . This application claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 60/697,590 filed on Jul. 11, 2005, which is hereby incorpor

US Patent for Synthesis of selective androgen receptor .

The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment .

JP2002504689A - Chemiluminescent compositions for use in .

JP2002504689A JP2000532729A JP2000532729A JP2002504689A JP 2002504689 A JP2002504689 A JP 2002504689A JP 2000532729 A JP2000532729 A JP 2000532729A JP 2000532729 A .

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HIV INTEGRASE INHIBITORS - MERCK & CO., INC.

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I), wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as .

Methods and compounds for producing dipeptidyl peptidase .

Nov 05, 2014 · VU, Truc Chi (472 Ridge Road, Watchung, NJ 07069, US) Kolotuchin, Sergei V. (123-B Jerome Street, Roselle Park, NJ 07204, US) Mazzullo Jr., John A. (115 Fairway Drive .

Process For Preparing Dipeptidyl Peptidase IV Inhibitors .

Abstract: A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure ##STR00001## prepared by subjecting an acid of the structure ##STR00002## to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified .

PHASE 3 – Page 3 - PHASE 3 « New Drug Approvals

110 ml of dry tetrahydrofuran was added to 7.6 ml of 1-methylimidazole (0.0946 mole) and the resulting solution cooled to -15°C.37.8 ml of n-hexyllithium 2.5 M in n-hexane (0.0946 mole) was added, while the temperature during addition was kept between – 5°C and 0°C.

2-Methyltetrahydrofuran | C5H10O - PubChem

methyl-tetrahydrofuran. Me-THF. 2-Methyletrahydrofuran. Methyl tetrahydrofurane. 2-methyltetrahyrdofuran. PubChem10841. 2-methyltetrahydrofurane. 2-methyl tetrahydrofurane. 2-methyl-tetrahydrofurane. EC 202-507-4. Tetrahydrofuran, 2-methyl-WLN: T5OTJ B1. DSSTox_CID_10258. DSSTox_RID_78841. DSSTox_GSID_30258. 5-17-01-00078 (Beilstein Handbook .

CN1665817A - Process for preparing certain pyrrolotriazine .

The present invention relates to a general formula (1) certain pyrrolotriazine compounds and salts of pharmaceutically acceptable. Compounds of formula (1) can inhibit the growth factor receptors such as VEGFR-2 and FGFR-1 tyrosine kinase activity, and therefore they can be used as anticancer agents. Formula (1) compounds can also be used to treat other signal transduction by growth factor .

Laboratory equipment - Verrerie Villeurbannaise

Magnetic stirrer,air or hydraulic pressure, diameter 128,5 mm height 61,3 mm, working by water pressure between 1 and 2,5 Kg /cm2 or by air pressure. For corrosion proof or expl

Rotovap | Is a registered Trademark 2017 | United States

Rotovap registered trade mark lab science plant oil extraction Rotovapur is a unique company we design and invent new lab technology and rotary evaporator machines glassware lab apparatus for plant science extractions based on 30 years working in Terpenes and alkoloids. Shop & Purchase rotovap. HOME. PRIVACY POLICY. SERVICES.

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0rphan drug status « New Drug Approvals « Page 9

Both were concentrated by rotovap to give oils (7.05 g and 1.84 g, 8.89 g total, > yield, HPLC purity -90%). The larger aliquot was used to generate hetone 1-4 as is. The smaller aliquot was dissolved in DCM (3.7 g, 2 parts) and placed on a pad of Si0 2 (5.5 g, 3 parts).

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Lab Equipment and Lab Supplies | Fisher Scientific

Fisher Scientific is the UK's leading supplier of laboratory equipment, chemicals, and services used in scientific research, safety, healthcare, and education.

USA Lab 50L Rotary Evaporator Rotovap RE-1050 - 180°C .

The USA Lab 50L RE Series rotary evaporator recovers solvents efficiently and fast.This unit provides consistent and repeatable results at an affordable price.With GG-17 High Borosilicate Glass, all pieces have been designed for efficient use of surface area. This means faster recovery without compromising quality.Our evaporators come standard with safety features such as over-temperature shut .

US Patent for Synthetic modification of Spinosyn compounds .

The compounds of the present invention are prepared directly or indirectly by modifying the compounds that are naturally produced from Saccharopolyspora spinosa. The compounds of the invention have been shown to have activity against insects and mites. The compounds are prepared by modifying the rhamnose sugar, modification of the forosamine sugar, or starting with pseuodoaglycone and then .